| Eddie Redmayne | Newt Scamander |
| Katherine Waterston | Porpentina "Tina" Goldstein |
| Dan Fogler | Jacob Kowalski |
| Alison Sudol | Queenie Goldstein |
| Colin Farrell | Percival Graves |
| Jon Voight | Henry Shaw Sr |
| Ron Perlman | Gnarlack |
| Johnny Depp | Gellert Grindelwald |
| Zoë Kravitz | Leta Lestrange |
| Ezra Miller | Credence Barebone |
| Samantha Morton | Mary Lou Barebone |
| Carmen Ejogo | Seraphina Picquery |
| Josh Cowdery | Henry Shaw, Jr |
| Ronan Raftery | Langdon Shaw |
| Faith Wood-Blagrove | Modesty Barebone |
| Jenn Murray | Chastity Barebone |
| Gemma Chan | Madame Ya Zou |
| Peter Breitmayer | Gilbert Bingley |
| Kevin Guthrie | Mr. Abernathy |
| Sean Cronin | Nearby Criminal |
| Sam Redford | Customs Official |
| Akin Gazi | Auror |
| Todd Boyce | The Announcer |
| Anne Wittman | Housewife |
| Andreea Păduraru | Auror 9 |
| Matthew Sim | Photographer 1 |
| Elizabeth Moynihan | Executioner #1 |
| Adam Lazarus | Wizard |
| Lucie Pohl | Secretary |
| Tim Bentinck | Witness |
| Bart Edwards | New York Chief of Police |
| Brian F. Mulvey | The Watchman |
| Tristan Tait | Reporter |
| Tom Clarke Hill | Photographer 2 |
| Cory Peterson | Bank Employee |
| Jake Samuels | Bank Guard |
| Max Cazier | Young Man |
| Dan Hedaya | Red |
| Christy Meyer | Guide - Inside Macusa |
| Guy Paul | Auror 2 |
| Walles Hamonde | Auror 10 |
| Dominique Tipper | Auror 1 |
| Leo Heller | Boy with Birthmark |
| Miles Roughley | Poor Boy |
| Erick Hayden | Policeman |
| Paul Birchard | Hobo |
| Tom Hodgkins | Barker |
| Ellie Haddington | Mrs. Esposito |
| Joseph Macnab | Police Officer 1 |
| Martin Oelbermann | Heinrich Eberstadt |
| Richard Clothier | British Envoy |
| Christian Dixon | Momolou Wotorson |
| Richard Hardisty | Auror 4 |
| Miquel Brown | Executioner #2 |
| Wunmi Mosaku | Beryl |
| Cristian Solimeno | Executioner #3 |
| Matthew Wilson | Sam the Obliviator |
| Aretha Ayeh | Singer - The Blind Pig Speakeasy |
| Emmi | Singer - The Blind Pig Speakeasy |
| Nicholas McGaughey | Australian Wizard |
| Arinzé Kene | Auror 6 |
| Jane Perry | Bakery Customer |
| Abi Adeyemi | International Royal Dignitar (uncredited) |
| Aileen Archer | Criminal (uncredited) |
| Lee Asquith-Coe | Officer 247 (uncredited) |
| Robert-Anthony Artlett | Upperclass Wizard (uncredited) |
| Alphonso Austin | Boat Crew (uncredited) |
| Michael Barron | New Yorker (uncredited) |
| Roy Beck | Senator Shaw's Speechwriter (uncredited) |
| Marc Benanti | Journalist (uncredited) |
| Nathan Benham | Bank Guard (uncredited) |
| Paul Bergquist | Gala Dinner Guest (uncredited) |
| Laura Bernardeschi | Italian Tenant in New York (uncredited) |
| David J Biscoe | Journalist (uncredited) |
| Lee Bolton | Photographer (uncredited) |
| Elizabeth Briand | Gala Guest (uncredited) |
| Neil Broome | Gala Dinner Guest (uncredited) |
| Greg Brummel | New York Tenement (uncredited) |
| Douglas Byrne | Gala Guest (uncredited) |
| Fanny Carbonnel | Mrs. Goldstein (uncredited) |
| David Charles-Cully | Gentleman (uncredited) |
| Stacey Clegg | Gala Dinner Guest (uncredited) |
| Chloe Collingwood | Taxi Passenger (uncredited) |
| Claire Cooper-King | Gala Dinner Guest (uncredited) |
| Carmen Cowell | Tenement Woman (uncredited) |
| Silvia Crastan | New Yorker (uncredited) |
| Craig Davies | New Yorker (uncredited) |
| Chloe de Burgh | Tenement Woman (uncredited) |
| Paul Dewdney | New York Journalist (uncredited) |
| Rudi Dharmalingam | Ranjit (uncredited) |
| Joshua Diffley | Young Husband (uncredited) |
| Nick Donald | Bank Customer (uncredited) |
| Richard Douglas | Gentleman (uncredited) |
| Henry Douthwaite | Skender (uncredited) |
| Stephanie Eccles | Gala Dinner Guest (uncredited) |
| Dino Fazzani | Factory Worker (uncredited) |
| Flor Ferraco | Bank Client (uncredited) |
| Marketa Flynn | New Yorker (uncredited) |
| Lobna Futers | Witch (uncredited) |
| Michael Gabbitas | Gala Guest (uncredited) |
| David Goodson | Porter (uncredited) |
| Kirsty Grace | Jazz Girl (uncredited) |
| Rudy Valentino Grant | New York Street Sweeper (uncredited) |
| Guna Gultniece | Immigrant (uncredited) |
| Abigayle Honeywill | Criminal (uncredited) |
| Luke Hope | NYC Banker (uncredited) |
| Kornelia Horvath | South American Passenger on Newt's Boat (uncredited) |
| Ashley Hudson | Young Gentleman (uncredited) |
| Alan Wyn Hughes | Gala Photographer (uncredited) |
| Alex Jaep | Pedestrian (uncredited) |
| Ian Jenkins | High Society Gentleman (uncredited) |
| Patrick Carney Junior | Gala Dinner Guest (uncredited) |
| Lampros Kalfuntzos | Male Passenger on Newt's Boat (uncredited) |
| Attila G. Kerekes | New York Citizen (uncredited) |
| Simon Kerrison | High Society Gentleman / Gala Guest (uncredited) |
| Denis Khoroshko | Banker Smirnoff (uncredited) |
| Cole Leman | Customs Officer (uncredited) |
| Adam Lezemore | Gala Guest (uncredited) |
| Paul Low-Hang | Pentagram Nobleman (uncredited) |
| Khristopher MacLeod | Higher Class Gentleman (uncredited) |
| Joe Malone | Young Wizard (uncredited) |
| Alan Mandel | Mr. Goldstein (uncredited) |
| Christopher Marsh | New York Banker (uncredited) |
| Jorge Leon Martinez | Spaniard Ship Passenger (uncredited) |
| Christine Marzano | Exterminator (uncredited) |
| Pete Meads | Factory Worker (uncredited) |
| Andy Mihalache | Bank Customer (uncredited) |
| Arnold Montey | Journalist (uncredited) |
| James M.L. Muller | Newsroom Reporter (uncredited) |
| Paul A Munday | Journalist (uncredited) |
| John Murray | Blind Pig Criminal (uncredited) |
| Dennis O'Donnell | Circus Escapologist (uncredited) |
| Yves O'Hara | Gala Dinner Guest (uncredited) |
| Andrew G. Ogleby | New York Factory Worker (uncredited) |
| Edd Osmond | Creature Performer (uncredited) |
| Andrew Parker | Gangster at Bar (uncredited) |
| Gino Picciano | Gangster (uncredited) |
| Richard Price | Gala Guest (uncredited) |
| Olivia Quinn | Aunt of the Bride (uncredited) |
| Paul Redfern | Gala Guest (uncredited) |
| Jason Redshaw | Higher Class Gentleman (uncredited) |
| Bernardo Santos | Smart New Yorker (uncredited) |
| Dave Simon | New York Socialite (uncredited) |
| David Soffe | Gala Dinner Guest (uncredited) |
| Ryan Storey | Waiter (uncredited) |
| Connor Sullivan | Gala Guest (uncredited) |
| Camilla Talarowska | New York Citizen (uncredited) |
| Dan Trotter | Street Vendor (uncredited) |
| Vassiliki Tzanakou | Boat Passenger (uncredited) |
| Geeta Vij | Auror (uncredited) |
| Morgan Walters | Watchman (uncredited) |
| Anick Wiget | Criminal on 'Wanted' Poster (uncredited) |
| Miroslav Zaruba | Bank Guard (uncredited) |
| Reid Anderson | Auror (uncredited) |
| Tineke Ann Robson | Auror (uncredited) |