 | Tom Holland | Peter Parker / Spider-Man |
 | Samuel L. Jackson | Nick Fury |
 | Jake Gyllenhaal | Quentin Beck / Mysterio |
 | Marisa Tomei | May Parker |
 | Jon Favreau | Harold "Happy" Hogan |
 | Zendaya | Michelle "MJ" Jones |
 | Jacob Batalon | Ned Leeds |
 | Tony Revolori | Eugene "Flash" Thompson |
 | Angourie Rice | Betty Brant |
 | Remy Hii | Brad Davis |
 | Martin Starr | Mr. Harrington |
 | J.B. Smoove | Mr. Dell |
 | Jorge Lendeborg Jr. | Jason Ionello |
 | Cobie Smulders | Maria Hill |
 | Numan Acar | Dimitri |
 | Zach Barack | Zach |
 | Zoha Rahman | Zoha |
 | Yasmin Mwanza | Yasmin |
 | Joshua Sinclair-Evans | Josh Spinelli |
| Tyler Luke Cunningham | Tyler |
| Sebastian Viveros | Sebastian |
 | Toni Garrn | The Seamstress |
 | Peter Billingsley | William Ginter Riva |
 | Clare Dunne | Victoria |
 | Nicholas Gleaves | Guterman |
 | Claire Rushbrook | Janice |
 | J.K. Simmons | J. Jonah Jameson |
| Dawn Michelle King | E.D.I.T.H. (voice) |
 | Jeroen van Koningsbrugge | Dutch Soccer Hooligan 1 |
 | Michael de Roos | Dutch Soccer Hooligan 2 |
 | Jan-Paul Buijs | Dutch Soccer Hooligan 3 |
 | Sergio Pierattini | Venetian Glassblower |
 | Anjana Vasan | Queens Reporter |
 | Brian Law | Queens Reporter |
 | Evelyn Mok | Queens Reporter |
| Tatiana Lunardon | Italian TV Newsreader |
 | Giada Benedetti | Italian Customs Office |
 | Lukáš Bech | Helpful Dutch Man |
 | Alessandro Giuggioli | Italian Street Vendor |
| Petr Opava | Opera Singer |
| Giuseppe Andriolo | Caricaturist |
 | Pat Kiernan | Himself |
| Shari Abdul | High School Reporter (uncredited) |
 | Maria Alexandrova | Tourist in Venice (uncredited) |
 | Kristen Alminta | Police Officer (uncredited) |
 | Vincent Angel | Midtown High Student (uncredited) |
 | Peter Arpesella | Airplane Pilot (uncredited) |
 | Lasco Atkins | Salvation Army guest (uncredited) |
| Sitara Attaie | Dutch Lady (uncredited) |
 | Peter Bankolé | Mob Boss (uncredited) |
 | Blair Barnette | Queens Reporter (uncredited) |
 | Tuwaine Barrett | Officer Bristow (extended cut) |
| Anna Benamati | Shop Owner in Venice (uncredited) |
 | Pierre Bergman | Venice Fish Seller (uncredited) |
| Avondre E.D. Beverley | High School Student (uncredited) |
 | Bruno Bilotta | Mob Boss (uncredited) |
 | Sharon Blynn | Soren (uncredited) |
| Luigi Boccanfuso | Italian Builder in Venice (uncredited) |
| Paolo Braghetto | Poliziotto (uncredited) |
| Dante Brattelli | High School Student (uncredited) |
 | Jeff Bridges | Obadiah Stane (archive footage) (uncredited) |
| Graham Burton | London Passerby (uncredited) |
| Ken Byrd | Post Office Customer (uncredited) |
 | Sokol Cahani | Mob Boss (uncredited) |
 | Gianni Calchetti | Venetian Fish Stall Owner (uncredited) |
 | Darren Lee Campbell | Victoria's Crew (uncredited) |
 | Hélène Cardona | Austrian Backpacker (uncredited) |
 | Dian Cathal | American Reporter (uncredited) |
 | Jake Cerny | Airport Traveler (uncredited) |
 | Komal Charania | High School Student Boom Operator (uncredited) |
 | Daphne Cheung | Passport Clerk (uncredited) |
| Sam Chuck | High School Student (uncredited) |
 | Al Clark | Cowboy Plane Passenger (uncredited) |
| Victoria Coburn | Passerby (uncredited) |
 | Kimberly Collison | Charity Event Mom (uncredited) |
| Tiziana Coste | Local Venetian (uncredited) |
 | Kevin Daigneault | Police Officer (uncredited) |
 | Jaylen Davis | Tourist (uncredited) |
 | Peter Dawson | Tourist in Venice (uncredited) |
| Kristianne-Kaith Domingo | Passerby (uncredited) |
| Andrew Dunkelberger | Courier (uncredited) |
| Charlie Rhea Esquér | Mexican Survivor (uncredited) |
 | Ria Fend | Tourist in Venice (uncredited) |
| Ferroz Fernandez | Tourist in Venice (uncredited) |
 | Vincent Frattini | Venice Local (uncredited) |
 | Massi Furlan | Flight Attendant (uncredited) |
| Cynthia Garbutt | Charity Dinner Guest (uncredited) |
| Thomas Goodridge | Tourist in Venice (uncredited) |
 | Sonia Goswami | Tourist (uncredited) |
| Nicholle Hembra | Saved Londoner (uncredited) |
 | Michael Hennessy | Hotel Guest (uncredited) |
 | Meagan Holder | Pretty Tourist (uncredited) |
 | Patrick Holly | Partygoer (uncredited) |
 | Ruth Horrocks | Tourist (uncredited) |
| Chris Hyacinthe | Sneezy Tour Guide (uncredited) |
 | Michael Iacono | Airport Kid Traveler (uncredited) |
| Roman Ibragimov | Bar Customer (uncredited) |
 | Theo Ip | Tourist (uncredited) |
| Timothy Christian Jansen | High School Student (uncredited) |
| Daham Kandanarrachchi | London Passerby (uncredited) |
| Keon Kendrick | Flight Attendant (uncredited) |
| Camille Kinloch | Midtown High School Student (uncredited) |
 | Michal Kubal | Czech TV News Anchor (uncredited) |
 | Hannah Kurczeski | Student (uncredited) |
 | Géraldine Lamarre | Traffic Warden (uncredited) |
 | Jimena Larraguivel | Mexican Villager (uncredited) |
 | Rich Lawton | Journalist (uncredited) |
 | Kath Leroy | Czech Traditional Dancer (uncredited) |
 | Gavin Lee Lewis | Londoner (uncredited) |
 | Faith Logan | High School Student (uncredited) |
 | Patrick Loh | Airport Passenger (uncredited) |
 | Joseph Long | Mob Boss (uncredited) |
 | Marian Lorencik | New Czech Reveler (uncredited) |
 | Ketan Majmudar | Berlin Commuter (uncredited) |
 | Tony Mardon | Londoner (uncredited) |
 | Antonín Mašek | Bellboy (uncredited) |
| Eustace Meade | Charity Attendant (uncredited) |
 | Ben Mendelsohn | Talos (uncredited) |
 | Bradley Wj Miller | Passerby (uncredited) |
 | Melissa Beth Miller | Tourist (uncredited) |
 | Anthony Molinari | Mob Guy (uncredited) |
| Julia Mollin | Flute Player (uncredited) |
 | Adrian Mozzi | Venice Local (uncredited) |
 | Brendan Murphy | Police Officer (uncredited) |
| Amanda Musso | Carnival Hot Girl (uncredited) |
 | Emily Ng | Italian Tourist (uncredited) |
 | Daniel Olson | Czech Guy (uncredited) |
| Karen Parks | Charity Event Attendee (uncredited) |
 | Hiten Patel | British Station Staff (uncredited) |
| Clay Pel-is | London Tourist (uncredited) |
 | Luigi Petrazzuolo | Gondolier (uncredited) |
| Aleksandrs Petukhovs | London Passerby (uncredited) |
 | Annie Pisapia | Traveler (uncredited) |
| Martin Polak | Czech Reveler (uncredited) |
 | Jivan Xander Ramesh | Pedestrian (uncredited) |
| Mike Ray | Passerby (uncredited) |
 | Sofia Renee | High School Student (uncredited) |
| Daniel Rennis | Cab Driver (uncredited) |
| Sawyer Reo | Young Brad Davis (uncredited) |
 | Cailan Robinson | Victoria's Crew (uncredited) |
 | Emmanuel Rodriguez | Airport Traveler (uncredited) |
 | Ray Rosario | TSA Agent (uncredited) |
 | Daniel Ryves | Dad Collecting Kids (uncredited) |
| Monae Samone | Midtown High Student (uncredited) |
 | Maurice Sardison | Party Goer (uncredited) |
| Susanne Schraps | Berlinerin (uncredited) |
| Karen-J Sear | American Tourist (uncredited) |
 | Ilya Tank Shilov | Venice Tourist (uncredited) |
 | Davina Sitaram | London Tourist (uncredited) |
 | Joakim Skarli | London Tourist (uncredited) |
| Paul Slim | Tourist (uncredited) |
| Richard Stanley | Charity Dinner Attendee (uncredited) |
| Lucas Antoine Starrets | Tourist (uncredited) |
 | Faith Tarby | Perfumed Lady (uncredited) |
 | Emily Tebbutt | Venice Tourist (uncredited) |
| Oskar Ulvestad | Street Pedestrian (uncredited) |
| Lesdy Vanessa | Tourist (uncredited) |
 | Jessica VanOss | Student (uncredited) |
 | Joe David Walters | Pawn Shop Owner (uncredited) |
| Jo Wheatley | Armed Security Officer (uncredited) |
| Dale Wilder | German Office Worker (uncredited) |
 | Rocco Wu | Peter's Art Classmate (uncredited) |
| Jan Zalabak | Tourist in Town (uncredited) |
| Samantha Mishinski | Student (uncredited) |
| Alessandro Sciarra | Screaming Kid (uncredited) |
| Aristou Meehan | Italian Boy (uncredited) |
91% 
95%